Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studySARS-COV-2 감염 및 급성 신장 손상 마커에 의해 유도 된 변경된 신장 기능 COVID-19 환자의 생존 결과를 예측합니다 : 전향 적 파일럿 연구Article Published on 2022-12-012022-08-31 Journal: Renal failure [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute kidney Acute kidney injury adjusted Advancing age Altered Analysis association Biomarker chronic Chronic kidney disease collaboration Comorbidities Comorbidity Control coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 COVID-19 patient COVID-19 patients creatinine Cumulative rates cystatin C death demonstrated elevated examined group groups Hospitalized ICU intensive care intensive care unit investigated Kaplan-Meier method kidney kidney damage Kidney disease Kidney function Kidney function tests Kidney injury literature marker morbidity multivariable Cox regression outcome participant pilot study predict Predictive Predictive value Proteinuria retained risk factor Risk factors SARS-COV-2 infection serum serum creatinine Sex significant difference statistically subject survival survival analysis survival analysis. the Kaplan-Meier method Treatment Urine with COVID-19 [DOI] 10.1080/0886022X.2022.2032743 PMC 바로가기 [Article Type] Article
Saliva as a Potential Specimen to Monitor IL-6, TNF-α and IL-10 in COVID-19 PatientsArticle Published on 2022-12-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 치료기술, [키워드] alleviate Blood blood specimen Clinical prognosis collected comparable COVID-19 COVID-19 patients cycle threshold detectable elevated elicited enrolled expressed expression human saliva IL-10 IL-10. IL-6 inclusion criteria Infection Inflammation Inflammation. Inflammatory Inflammatory cytokine inflammatory gene Lung injury marker MINI Mortality Patient pilot study Potential protocols Qiagen RNA RT-PCR Saliva SARS-CoV-2 severe cases specimen subject the mean TNF-α were assessed [DOI] 10.1007/s10753-022-01698-x PMC 바로가기
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
Sensitive detection of SARS-CoV-2 molecular markers in urban community sewersheds using automated viral RNA purification and digital droplet PCRArticle Published on 2022-11-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] affecting approach automated Care Community correlation COVID-19 COVID-19 case detection of marker Detroit disadvantage Effectiveness Epidemiology faster Final handling Health identify inhibitor Local marker molecular number of sample outbreak PCR PerkinElmer Prevent Promega public health authority purification required RNA RNA purification SARS-CoV-2 sensitive sensitivity Standard state the SARS-CoV-2 virus Thermofisher time-consuming Viral RNA Volume wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157547 PMC 바로가기
Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasiaArticle Published on 2022-11-072022-11-16 Journal: Orphanet Journal of Rare Diseases [Category] 유전자 메커니즘, [키워드] analysis Angiogenesis assigned Biomarkers bleeding Blood center double-blind doxycycline Effectiveness ENG Epistaxis Frequency heart failure help hemorrhage Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia Hereditary hemorrhagic telangiectasia. HHT IL-6 Inflammatory intravenous limitations Liver disease malformation marker mechanism Michael morbidity no significant difference not significantly different observation pathway Patient Placebo placebo-controlled provided Quality of life Randomized controlled trial Randomly RBC recruited Registered Registration secondary significantly higher stroke telangiectasia therapy Toronto Treatment treatment period Trial VEGF [DOI] 10.1186/s13023-022-02539-8 PMC 바로가기
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
Serum hydroxybutyrate dehydrogenase and COVID-19 severity and mortality: a systematic review and meta-analysis with meta-regressionArticle Published on 2022-11-012022-11-15 Journal: Clinical and experimental medicine [Category] 바이오마커, [키워드] 95% CI Admission alteration Analysis Biomarker certainty of evidence Concentration conducted coronavirus disease COVID-19 COVID-19 patients COVID-19 severity disease severity effect size Egger estimates heterogeneity hospitalized COVID-19 patient hydroxybutyrate hydroxybutyrate dehydrogenase Inflammation Injury Liver damage magnitude marker Meta-analysis meta-regression moderate Mortality mortality. Myocardial myocardial injury non-specific non-survivor Patient performed renal renal function reported risk stratification searched Sepsis serum severity significantly significantly higher SMD standardized mean difference survival survivor systematic review tissue damage Web of Science [DOI] 10.1007/s10238-021-00777-x PMC 바로가기
Clinical, laboratory and immunohistochemical characterization of in situ pulmonary arterial thrombosis in fatal COVID-19Article Published on 2022-11-012022-11-15 Journal: Thrombosis research [Category] SARS, 바이오마커, [키워드] Admission age Artery characterized clinical Coagulopathy composed contribute controls coronavirus COVID-19 COVID-19 patient Critical disease D-dimer died disease disease severity elevations eosin evaluated Evidence fatal COVID-19 FEU Hypoxemia ICU immunohistochemistry in both groups Inflammation Inflammatory IQR Laboratory laboratory feature LDH lung main role marker neutrophil organ damage parenchymal damage Patient Platelet Pneumonia pneumonia case post-mortem lung pulmonary thrombi selected serum significantly higher thrombosis thrombosis. transfer WBC White blood cell [DOI] 10.1016/j.thromres.2022.09.012 PMC 바로가기
Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID-19 vaccineArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analyzed antibody Antibody titer B cell booster booster dose caused Cell Cluster Concentration conducted COVID-19 COVID-19 vaccine CyTOF Cytometry declined decrease distribution Efficacy ENhance healthy highlight humoral Immune cell immune response Immunity immunization immunoassay immunoassay. immunological profile inactivated individual injection Injections lack maintain marker multicenter neutralizing antibody not significantly different participant prevalence of COVID-19 proportion protective effect recall receiving recruited reduced SARS-CoV-2 second dose serum antibody shown significantly significantly increased Still subject surface marker sVNT the antibody response the vaccine vaccination Vaccine vaccine doses vaccine injection Viral variants virus neutralization test [DOI] 10.1002/jmv.27983 PMC 바로가기